Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation
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چکیده
منابع مشابه
Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation.
Animal models are often used to test the effectiveness of a drug or procedure before proceeding to clinical trials. One reason for use of animal models is that they allow researchers to focus on particular pathological processes without the confounding effects of other injuries and treatments. However, it is essential that their results are valid and precise. Biased or imprecise results from an...
متن کاملSystematic reviews of animal experiments.
There are strong scientific, ethical and legislative imperatives to replace animal experiments, rather than focusing efforts on improving them. Therefore, the Dr Hadwen Trust advocates that when systematic reviews identify weaknesses in animal experiments, the priority should be their replacement with more relevant non-animal methods. Individual researchers, universities, companies, funders and...
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Background and Objective: It has been reported that allopathic drugs do not have significant effects on diabetes treatment. In contemporary literature, much attention has been given to the potential use of traditional medicines, including medicinal plants, in the treatment of metabolic abnormalities. Indeed, the effect of Securigera securidaca, as a medicinal agent, in alleviating the complicat...
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Widespread reliance on animal models during preclinical research and toxicity testing assumes their reasonable predictivity for human outcomes. However, of 20 published systematic reviews examining human clinical utility, located during a comprehensive literature search, animal models demonstrated significant potential to contribute toward the development of clinical interventions in only two c...
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ژورنال
عنوان ژورنال: BMJ
سال: 2002
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.324.7335.474